Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans.

@article{Cruz1999RapamycinAA,
  title={Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans.},
  author={M{\'a}rio Costa Cruz and Lora M. Cavallo and J M G{\"o}rlach and Giles Cox and John R Perfect and Maria Elena Cardenas and Joseph Heitman},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 6},
  pages={4101-12}
}
Cryptococcus neoformans is a fungal pathogen that causes meningitis in patients immunocompromised by AIDS, chemotherapy, organ transplantation, or high-dose steroids. Current antifungal drug therapies are limited and suffer from toxic side effects and drug resistance. Here, we defined the targets and mechanisms of antifungal action of the immunosuppressant rapamycin in C. neoformans. In the yeast Saccharomyces cerevisiae and in T cells, rapamycin forms complexes with the FKBP12 prolyl isomerase… CONTINUE READING

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Cryptococcus neoformans

  • A. Casadevall, J. R. Perfect
  • 1998
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