Rapamycin, an mTOR inhibitor, induced apoptosis via independent mitochondrial and death receptor pathway in retinoblastoma Y79 cell.

Abstract

Rapamycin is helpful in the treatment of certain cancers by inhibiting mTOR (mammalian target of rapamycin) pathway. Here, rapamycin mediated apoptosis were investigated in human retinoblastoma Y79 cells. The MTT assay showed that the IC50 value of rapamycin against Y79 cells was 0.136 ± 0.032 μmol/L. Flow cytometry analysis indicated that the percentage of… (More)

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@article{Wang2015RapamycinAM, title={Rapamycin, an mTOR inhibitor, induced apoptosis via independent mitochondrial and death receptor pathway in retinoblastoma Y79 cell.}, author={Yangyang Wang and Yong-Jing Su and Jianying Li and Xiang-Chao Yao and Guang-Jiang Liang}, journal={International journal of clinical and experimental medicine}, year={2015}, volume={8 7}, pages={10723-30} }