Rapamycin ameliorates chitosan nanoparticle-induced developmental defects of preimplantation embryos in mice

@inproceedings{Choi2016RapamycinAC,
  title={Rapamycin ameliorates chitosan nanoparticle-induced developmental defects of preimplantation embryos in mice},
  author={Yun-Jung Choi and Sangiliyandi Gurunathan and Dasom Kim and Hyung Seok Jang and Woo-Jin Park and Ssang-Goo Cho and Chankyu Park and Hyuk Song and Han Geuk Seo and Jin-Hoi Kim},
  booktitle={Oncotarget},
  year={2016}
}
Chitosan nanoparticles (CSNPs) are used as drug or gene delivery vehicles. However, a detailed understanding of the effects of CSNPs on embryonic development remains obscure. Here, we show that CSNPs can be internalized into mouse blastocysts, such as the zona pellucida, the perivitelline space, and the cytoplasm. Consequently, CSNPs-induced endoplasmic reticulum (ER) stress increases both of Bip/Grp78, Chop, Atf4, Perk, and Ire1a mRNAs expression levels, and reactive oxygen species. Moreover… CONTINUE READING
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