Rapamycin adjuvant and exacerbation of severe influenza in an experimental mouse model

@inproceedings{Huang2017RapamycinAA,
  title={Rapamycin adjuvant and exacerbation of severe influenza in an experimental mouse model},
  author={Ching-Tai Huang and Chen-Yiu Hung and Tse-Ching Chen and Chun-Yen Lin and Yung-Chang Lin and Chia-Shiang Chang and Yueh-Chia He and Yu-Lin Huang and Avijit Dutta},
  booktitle={Scientific Reports},
  year={2017}
}
Influenza virus infection often causes severe disease and acute respiratory distress syndrome. It is a common belief that overwhelming immune response contributes to the severe illness. Physicians and researchers have put forth immune modulation as salvage therapy for better recovery. However, empiric corticosteroid failed in both humans and animal models. Reported success with Rapamycin in humans prompted a comprehensive animal study and mechanistic dissection. Here we report the effect of… CONTINUE READING
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