Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson-Gilford Progeria Syndrome Cells

@article{Cao2011RapamycinRC,
  title={Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson-Gilford Progeria Syndrome Cells},
  author={Kan Cao and John J Graziotto and Cecilia D Blair and Joseph R Mazzulli and M. Erdos and D. Krainc and F. Collins},
  journal={Science Translational Medicine},
  year={2011},
  volume={3},
  pages={89ra58 - 89ra58}
}
  • Kan Cao, John J Graziotto, +4 authors F. Collins
  • Published 2011
  • Biology, Medicine
  • Science Translational Medicine
  • Shown previously to extend longevity in animals, the drug rapamycin might serve as a treatment for a human premature aging syndrome. The Young and the Youthless In the novel Brideshead Revisited, Evelyn Waugh reminisces about “the langor of youth” and laments “how quickly, how irrecoverably lost” is the bloom. Although every adult can relate to this cri de coeur, in no case is youth lost more swiftly or more dramatically than in children suffering from Hutchinson-Gilford progeria syndrome (HGPS… CONTINUE READING
    273 Citations
    Rapamycin activates autophagy in Hutchinson-Gilford progeria syndrome
    • 64
    • PDF
    Analysis of phenotype reversibility in Hutchinson-Gilford progeria syndrome in mice
    Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells
    • 3
    Sulforaphane enhances progerin clearance in Hutchinson–Gilford progeria fibroblasts
    • 64
    • PDF

    References

    SHOWING 1-10 OF 44 REFERENCES
    A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model
    • 177
    • PDF
    Phenotype and course of Hutchinson-Gilford progeria syndrome.
    • 192
    Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.
    • 530
    Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy.
    • 1,033
    • PDF
    A lamin A protein isoform overexpressed in Hutchinson–Gilford progeria syndrome interferes with mitosis in progeria and normal cells
    • 228
    • PDF
    Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson–Gilford progeria syndrome
    • 879
    • PDF
    Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome.
    • 335
    • PDF
    Rapamycin alleviates toxicity of different aggregate-prone proteins.
    • 587
    • PDF
    Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    • 2,642
    • PDF