Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson-Gilford Progeria Syndrome Cells

  title={Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson-Gilford Progeria Syndrome Cells},
  author={Kan Cao and John J Graziotto and Cecilia D Blair and Joseph R Mazzulli and M. Erdos and D. Krainc and F. Collins},
  journal={Science Translational Medicine},
  pages={89ra58 - 89ra58}
  • Kan Cao, John J Graziotto, +4 authors F. Collins
  • Published 2011
  • Biology, Medicine
  • Science Translational Medicine
  • Shown previously to extend longevity in animals, the drug rapamycin might serve as a treatment for a human premature aging syndrome. The Young and the Youthless In the novel Brideshead Revisited, Evelyn Waugh reminisces about “the langor of youth” and laments “how quickly, how irrecoverably lost” is the bloom. Although every adult can relate to this cri de coeur, in no case is youth lost more swiftly or more dramatically than in children suffering from Hutchinson-Gilford progeria syndrome (HGPS… CONTINUE READING
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