Rapamycin Regulates iTreg Function through CD39 and Runx1 Pathways

Abstract

It has been shown that rapamycin is able to significantly increase the expression of FoxP3 and suppress activity in induced Treg (iTreg) cells in vivo and in vitro. CD39 is a newly determined Treg marker that relates to cell suppression. Runx1, a regulator of FoxP3, controls the expression of adenosine deaminase (ADA) gene, which is found recently in the… (More)
DOI: 10.1155/2014/989434

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