Rapamycin Protects Sepsis-Induced Cognitive Impairment in Mouse Hippocampus by Enhancing Autophagy

@article{Liu2016RapamycinPS,
  title={Rapamycin Protects Sepsis-Induced Cognitive Impairment in Mouse Hippocampus by Enhancing Autophagy},
  author={Wenyu Liu and Jia’nan Guo and Jie Mu and Linyu Tian and Dong Zhou},
  journal={Cellular and Molecular Neurobiology},
  year={2016},
  volume={37},
  pages={1195-1205}
}
The purpose of this study is to test the hypothesis that the mammalian target of rapamycin (mTOR) signaling pathway might mediate neuroprotection in a mouse model of septic encephalopathy and also to identify the role of autophagy. Mice were subjected to cecal ligation and puncture (CLP) or a sham operation, and all 50 mice were randomly assigned to five groups: sham, CLP+ saline, CLP+ rapamycin (1, 5, 10 mg/kg) groups. Two weeks after the operation, Morris water maze was conducted for… CONTINUE READING
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) Autophagy

  • DJ Klionsky
  • 2016

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