Rapamycin Does Not Impede Survival or Induction of Antibody Responses to Primary and Heterosubtypic Influenza Infections in Mice.

@article{Liepkalns2016RapamycinDN,
  title={Rapamycin Does Not Impede Survival or Induction of Antibody Responses to Primary and Heterosubtypic Influenza Infections in Mice.},
  author={Justine S. Liepkalns and Aseem Pandey and Amelia Ruth Hofstetter and Amrita Kumar and Enitra N Jones and Weiping Cao and Feng Liu and Min Z. Levine and Suryaprakash Sambhara and Sreeramaiah N. Gangappa},
  journal={Viral immunology},
  year={2016},
  volume={29 8},
  pages={487-493}
}
Impairment of immune defenses can contribute to severe influenza infections. Rapamycin is an immunosuppressive drug often used to prevent transplant rejection and is currently undergoing clinical trials for treating cancers and autoimmune diseases. We investigated whether rapamycin has deleterious effects during lethal influenza viral infections. We treated mice with two concentrations of rapamycin and infected them with A/Puerto Rico/8/1934 (A/PR8), followed by a heterosubtypic A/Hong Kong/1… CONTINUE READING

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