Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic Mice

@inproceedings{Ozcelik2013RapamycinAT,
  title={Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic Mice},
  author={Sefika Ozcelik and Graham G. Fraser and Perrine Castets and V{\'e}ronique Schaeffer and Zhiva K Skachokova and Karin S Breu and Florence Clavaguera and Michael Sinnreich and Ludwig Kappos and Michel Goedert and Markus Tolnay and David Theo Winkler},
  booktitle={PloS one},
  year={2013}
}
Altered autophagy contributes to the pathogenesis of Alzheimer's disease and other tauopathies, for which curative treatment options are still lacking. We have recently shown that trehalose reduces tau pathology in a tauopathy mouse model by stimulation of autophagy. Here, we studied the effect of the autophagy inducing drug rapamycin on the progression of tau pathology in P301S mutant tau transgenic mice. Rapamycin treatment resulted in a significant reduction in cortical tau tangles, less tau… CONTINUE READING
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