Rapamycin (AY-22,989), a new antifungal antibiotic. IV. Mechanism of action.

  title={Rapamycin (AY-22,989), a new antifungal antibiotic. IV. Mechanism of action.},
  author={K Singh and Shaoguang Sun and Camilla Vezina},
  journal={The Journal of antibiotics},
  volume={32 6},
Rapamycin, an antifungal antibiotic produced by Streptomyces hygroscopicus showed a strong candicidal activity, which could not be reversed by sterols. It has no effect on efflux of K+, Pi ir U.V. absorbing materials and cell permeability of Candida albicans. Thus, in its action it differs from the polyenes. Mechanism of action of rapamycin appears to be different from many known antifungal agents. In C. albicans, rapamycin at the minimum growth inhibitory concentration inhibited: 1) phosphate… CONTINUE READING


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