Rapamycin‐sensitive signalling in long‐term consolidation of auditory cortex‐dependent memory

@article{Tischmeyer2003RapamycinsensitiveSI,
  title={Rapamycin‐sensitive signalling in long‐term consolidation of auditory cortex‐dependent memory},
  author={Wolfgang Tischmeyer and Horst Schicknick and Michaela Kraus and Constanze I. Seidenbecher and Sabine Staak and Henning Scheich and Eckart D. Gundelfinger},
  journal={European Journal of Neuroscience},
  year={2003},
  volume={18}
}
New memories initially persist in a labile state and require protein synthesis‐dependent processes of consolidation for long‐term manifestation. Using differential conditioning to linearly frequency‐modulated tones (FMs) we have recently shown that post‐training injections of protein synthesis inhibitors into the auditory cortex of Mongolian gerbils interfere with long‐term memory for a number of days. Here, we have used rapamycin as a pharmacological tool to elucidate signalling pathways that… Expand
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