Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling

@article{Sebzda2002Rap1APR,
  title={Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling},
  author={Eric Sebzda and Michael Bracke and Tamara Tugal and Nancy Hogg and Doreen A Cantrell},
  journal={Nature Immunology},
  year={2002},
  volume={3},
  pages={251-258}
}
T cell receptor (TCR) stimulation activates the small GTPase Rap1A, which is reported to antagonize Ras signaling and induces T cell anergy. To address its role in vivo, we generated transgenic mice that constitutively expressed active Rap1A within the T cell lineage. We found that active Rap1A did not interfere with the Ras signaling pathway or antagonize T cell activation. Instead of anergy, the T lymphocytes that constitutively expressed active Rap1A showed enhanced TCR-mediated responses… CONTINUE READING
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