Rap1 regulates E-cadherin-mediated cell-cell adhesion.

  title={Rap1 regulates E-cadherin-mediated cell-cell adhesion.},
  author={Leo S. Price and Amra Hajdo-Milasinovi{\'c} and Jian Zhao and Fried J. T. Zwartkruis and John G. Collard and J. L. Bos},
  journal={The Journal of biological chemistry},
  volume={279 34},
The small GTPase Rap is best characterized as a critical regulator of integrin-mediated cell adhesion, although its mechanism of action is not understood. Rap also influences the properties of other cell-surface receptors and biological processes, although whether these are a consequence of effects on integrins is not clear. We show here that Rap also plays an important role in the regulation of cadherin-mediated cell-cell adhesion in epithelial cells. Expression of constitutively active Rap1A… CONTINUE READING


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