Rap1 protein regulates telomere turnover in yeast.

  title={Rap1 protein regulates telomere turnover in yeast.},
  author={Anat Krauskopf and Elizabeth H Blackburn},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 21},
Telomere length is maintained through a dynamic balance between addition and loss of the terminal telomeric DNA. Normal telomere length regulation requires telomerase as well as a telomeric protein-DNA complex. Previous work has provided evidence that in the budding yeasts Kluyveromyces lactis and Saccharomyces cerevisiae, the telomeric double-stranded DNA binding protein Rap1p negatively regulates telomere length, in part by nucleating, by its C-terminal tail, a higher-order DNA binding… CONTINUE READING

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