Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ₃.

@article{Lakshmikanthan2011Rap1PV,
  title={Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ₃.},
  author={Sribalaji Lakshmikanthan and Magdalena Sobczak and Changzoon Chun and Angela M Henschel and Jillian Dargatz and Ramani Ramchandran and Magdalena Chrzanowska-Wodnicka},
  journal={Blood},
  year={2011},
  volume={118 7},
  pages={2015-26}
}
Vascular endothelial growth factor (VEGF) acting through VEGF receptor 2 (VEGFR2) on endothelial cells (ECs) is a key regulator of angiogenesis, a process essential for wound healing and tumor metastasis. Rap1a and Rap1b, 2 highly homologous small G proteins, are both required for angiogenesis in vivo and for normal EC responses to VEGF. Here we sought to determine the mechanism through which Rap1 promotes VEGF-mediated angiogenesis. Using lineage-restricted Rap1-knockout mice we show that Rap1… CONTINUE READING
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