Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth

@article{Hisata2007Rap1PDZGEF1IW,
  title={Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth},
  author={Shu Hisata and Toshiaki Sakisaka and Takeshi Baba and Tomohiro Yamada and Kazuhiro Aoki and Michiyuki Matsuda and Yoshimi Takai},
  journal={The Journal of Cell Biology},
  year={2007},
  volume={178},
  pages={843 - 860}
}
Neurotrophins, such as NGF and BDNF, induce sustained activation of Rap1 small G protein and ERK, which are essential for neurite outgrowth. We show involvement of a GDP/GTP exchange factor (GEF) for Rap1, PDZ-GEF1, in these processes. PDZ-GEF1 is activated by GTP-Rap1 via a positive feedback mechanism. Upon NGF binding, the TrkA neurotrophin receptor is internalized from the cell surface, passes through early endosomes, and arrives in late endosomes. A tetrameric complex forms between PDZ-GEF1… CONTINUE READING
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