Rap1 Ameliorates Renal Tubular Injury in Diabetic Nephropathy

  title={Rap1 Ameliorates Renal Tubular Injury in Diabetic Nephropathy},
  author={Li Xiao and Xuejing Zhu and Shikun Yang and F. -Y. Liu and Zhiguang Zhou and Ming Zhan and Ping Xie and Dongshan Zhang and Jun Li and Panai Song and Yashpal S. Kanwar and Lin Yan Sun},
Rap1b ameliorates high glucose (HG)-induced mitochondrial dysfunction in tubular cells. However, its role and precise mechanism in diabetic nephropathy (DN) in vivo remain unclear. We hypothesize that Rap1 plays a protective role in tubular damage of DN by modulating primarily the mitochondria-derived oxidative stress. The role and precise mechanisms of Rap1b on mitochondrial dysfunction and of tubular cells in DN were examined in rats with streptozotocin (STZ)-induced diabetes that have Rap1b… CONTINUE READING