Ranolazine shortens repolarization in patients with sustained inward sodium current due to type-3 long-QT syndrome.

@article{Moss2008RanolazineSR,
  title={Ranolazine shortens repolarization in patients with sustained inward sodium current due to type-3 long-QT syndrome.},
  author={Arthur J. Moss and Wojciech Zareba and Karl Q. Schwarz and Spencer Z Rosero and Scott McNitt and Jennifer L. Robinson},
  journal={Journal of cardiovascular electrophysiology},
  year={2008},
  volume={19 12},
  pages={1289-93}
}
INTRODUCTION One form of the hereditary long-QT syndrome, LQT3-Delta KPQ, is associated with sustained inward sodium current during membrane depolarization. Ranolazine reduces late sodium channel current, and we hypothesized that ranolazine would have beneficial effects on electrical and mechanical cardiac function in LQT3 patients with the SCN5A-DeltaKPQ mutation. METHODS We assessed the effects of 8-hour intravenous ranolazine infusions (45 mg/h for 3 hours followed by 90 mg/h for 5 hours… CONTINUE READING

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