Ranolazine promotes muscle differentiation and reduces oxidative stress in C2C12 skeletal muscle cells

@inproceedings{Ileana2016RanolazinePM,
  title={Ranolazine promotes muscle differentiation and reduces oxidative stress in C2C12 skeletal muscle cells},
  author={Terruzzi Ileana and Montesano Anna and Senesi Pamela and Vacante Fernanda and Benedini Stefano and Luzi Livio},
  booktitle={Endocrine},
  year={2016}
}
The purpose of this study is to investigate Ranolazine action on skeletal muscle differentiation and mitochondrial oxidative phenomena. Ranolazine, an antianginal drug, which acts blocking the late INaL current, was shown to lower hemoglobin A1c in patients with diabetes. In the present study, we hypothesized an action of Ranolazine on skeletal muscle cells regeneration and oxidative process, leading to a reduction of insulin resistance. 10 μM Ranolazine was added to C2C12 murine myoblastic… CONTINUE READING