Ranolazine preserves and improves left ventricular ejection fraction and autonomic measures when added to guideline-driven therapy in chronic heart failure

@inproceedings{Murray2014RanolazinePA,
  title={Ranolazine preserves and improves left ventricular ejection fraction and autonomic measures when added to guideline-driven therapy in chronic heart failure},
  author={Gary L. Murray and Joseph Colombo},
  booktitle={Heart international},
  year={2014}
}
BACKGROUND Ranolazine (RAN) reduces cardiac sodium channel 1.5's late sodium current in congestive heart failure (CHF), reducing myocardial calcium overload, potentially improving left ventricular (LV) function. RAN blocks neuronal sodium channel 1.7, potentially altering parasympathetic and sympathetic (P&S) activity. The effects of RAN on LV ejection fraction (LVEF) and P&S function in CHF were studied. METHODS Matched CHF patients were given open-label RAN (1000 mg po-bid) added to… CONTINUE READING

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