Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts--role of late sodium current and intracellular ion accumulation.

Abstract

The goal of this study was to test the hypothesis that the novel anti-ischemic drug ranolazine, which is known to inhibit late I(Na), could reduce intracellular [Na(+)](i) and diastolic [Ca(2+)](i) overload and improve diastolic function. Contractile dysfunction in human heart failure (HF) is associated with increased [Na(+)](i) and elevated diastolic [Ca(2… (More)
DOI: 10.1016/j.yjmcc.2008.03.006

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Cite this paper

@article{Sossalla2008RanolazineID, title={Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts--role of late sodium current and intracellular ion accumulation.}, author={Samuel T. Sossalla and Stefan Wagner and Eva C. L. Rasenack and Hanna M. Ruff and Sarah Weber and Friedrich Albert Schoendube and Theodor Tirilomis and Gero Tenderich and Gerd Hasenfuss and Luiz Belardinelli and Lars Siegfried Maier}, journal={Journal of molecular and cellular cardiology}, year={2008}, volume={45 1}, pages={32-43} }