Ranking viruses: measures of positional importance within networks define core viruses for rational polyvalent vaccine development

@article{Anderson2012RankingVM,
  title={Ranking viruses: measures of positional importance within networks define core viruses for rational polyvalent vaccine development},
  author={Tavis K. Anderson and William W. Laegreid and Francesco Cerutti and Fernando A. Osorio and Eric A. Nelson and Jane Christopher-Hennings and Tony L. Goldberg},
  journal={Bioinformatics},
  year={2012},
  volume={28 12},
  pages={
          1624-32
        }
}
MOTIVATION The extraordinary genetic and antigenic variability of RNA viruses is arguably the greatest challenge to the development of broadly effective vaccines. No single viral variant can induce sufficiently broad immunity, and incorporating all known naturally circulating variants into one multivalent vaccine is not feasible. Furthermore, no objective strategies currently exist to select actual viral variants that should be included or excluded in polyvalent vaccines. RESULTS To address… 

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