Ranking the role of RANK ligand in apoptosis

  title={Ranking the role of RANK ligand in apoptosis},
  author={A. C. Bharti and Bharat Bhushan Aggarwal},
Many members of tumor necrosis factor (TNF) superfamily are characterized by their ability to induce apoptosis once they bind in a homotrimeric manner to their cognate receptors. The receptor activator of nuclear factor-κB ligand (RANKL), a member of the TNF superfamily identified seven years ago, was originally described as a factor that induced osteoclastogenesis and dendritic cell survival. Recent observations indicate that a growth inhibitory and apoptosis-inducing activity is associated… CONTINUE READING

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