Ranking Valid Topologies of the Secondary Structure Elements Using a Constraint Graph

  title={Ranking Valid Topologies of the Secondary Structure Elements Using a Constraint Graph},
  author={Kamal Al-Nasr and Desh Ranjan and Mohammad Zubair and Jing He},
  journal={Journal of bioinformatics and computational biology},
  volume={9 3},
Electron cryo-microscopy is a fast advancing biophysical technique to derive three-dimensional structures of large protein complexes. Using this technique, many density maps have been generated at intermediate resolution such as 6-10 Å resolution. Although it is challenging to derive the backbone of the protein directly from such density maps, secondary structure elements such as helices and β-sheets can be computationally detected. Our work in this paper provides an approach to enumerate the… 

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