Ranitidine in the treatment of duodenal ulcer disease: relationship between antisecretory effect and ulcer healing rate.

@article{McIsaac1991RanitidineIT,
  title={Ranitidine in the treatment of duodenal ulcer disease: relationship between antisecretory effect and ulcer healing rate.},
  author={Richard L. McIsaac and Julian S Dixon and John G Mills and John R. Wood},
  journal={Alimentary pharmacology & therapeutics},
  year={1991},
  volume={5 3},
  pages={227-43}
}
The relationship between drug-induced suppression of intragastric acidity and the rate of duodenal ulcer healing was examined using data for a single drug, ranitidine, from 156 clinical trials involving 16,362 patients together with data on acid suppression from 37 studies of intragastric acidity in 630 subjects. In these studies ranitidine was given in doses ranging from 150 mg to 1200 mg per day administered in 9 different dosage regimens. The overall percentage of patients whose duodenal… CONTINUE READING

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