Range and sensitivity as descriptors of molecular property spaces in dynamic QSAR analyses.

Abstract

In this paper, we report the first study aimed at correlating pharmacological properties with molecular parameters derived from the physicochemical property space of bioactive molecules. A dataset of 36 ligands of the alpha(1a)-, alpha(1b)-, and alpha(1d)-adrenoceptors as published by Bremner et al. (Bioorg. Med. Chem. 2000, 8, 201-214) was used. One… (More)

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Cite this paper

@article{Vistoli2005RangeAS, title={Range and sensitivity as descriptors of molecular property spaces in dynamic QSAR analyses.}, author={Giulio Vistoli and Alessandro Pedretti and Luigi Villa and Bernard Testa}, journal={Journal of medicinal chemistry}, year={2005}, volume={48 15}, pages={4947-52} }