Randomized trial with or without granulocyte colony-stimulating factor as adjunct to induction VNCOP-B treatment of elderly high-grade non-Hodgkin's lymphoma.

@article{Zinzani1997RandomizedTW,
  title={Randomized trial with or without granulocyte colony-stimulating factor as adjunct to induction VNCOP-B treatment of elderly high-grade non-Hodgkin's lymphoma.},
  author={Pier Luigi Zinzani and Enzo Pavone and Stefano Storti and Luciano Moretti and Pier Paolo Fattori and Luciano Guardigni and Brunangelo Falini and Marco Gobbi and Patrizia Gentilini and Vito Michele Lauta and Maurizio Bendandi and Filippo Gherlinzoni and Massimo Magagnoli and Sebastiano Venturi and Enrico Aitini and Michela Tabanelli and Giuseppe Leone and Vincenzo Liso and Sante Tura},
  journal={Blood},
  year={1997},
  volume={89 11},
  pages={3974-9}
}
Age is an important prognostic parameter, especially in patients with advanced high-grade non-Hodgkin's lymphoma (HG-NHL) who require more intensive and extensive therapy for any possible chance of cure. We investigated the potential of granulocyte colony-stimulating factor (G-CSF) for reducing myelotoxicity, which is the most important dose-limiting factor for chemotherapy. Between March 1993 and June 1995, 158 previously untreated patients 60 years and older with HG-NHL were included in a… CONTINUE READING
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