Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS).

@article{Flather2005RandomizedTT,
  title={Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS).},
  author={Marcus D. Flather and Marcelo C. Shibata and Andrew J. Stewart Coats and Dirk Jan van Veldhuisen and Aleksandr Yu. Parkhomenko and Joszef Borbola and A. Cohen-solal and Dan Dumitru Dumitrascu and R Silvana Ferrari and Ph. Lechat and Jordi Soler-Soler and Luigi Tavazzi and Lenka {\vS}pinarov{\'a} and Jir{\'i} Toman and Michael B{\"o}hm and Stefan D. Anker and Simon Giles Thompson and P. A. Poole-wilson},
  journal={European heart journal},
  year={2005},
  volume={26 3},
  pages={
          215-25
        }
}
AIMS Large randomized trials have shown that beta-blockers reduce mortality and hospital admissions in patients with heart failure. The effects of beta-blockers in elderly patients with a broad range of left ventricular ejection fraction are uncertain. The SENIORS study was performed to assess effects of the beta-blocker, nebivolol, in patients >/=70 years, regardless of ejection fraction. METHODS AND RESULTS We randomly assigned 2128 patients aged >/=70 years with a history of heart failure… CONTINUE READING

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