Randomized trial of pallidotomy versus medical therapy for Parkinson's disease.

  title={Randomized trial of pallidotomy versus medical therapy for Parkinson's disease.},
  author={Jerrold L. Vitek and R. Bakay and Alan R. Freeman and Marian Leslie Evatt and Joanne Connor Green and William H. McDonald and Michael Haber and Huiman H Barnhart and Natalie A Wahlay and Shirley D Triche and Klaus Mewes and Vijay Chockkan and Jian-yu Zhang and Mahlon R. Delong},
  journal={Annals of neurology},
  volume={53 5},
Thirty-six patients with Parkinson's disease (PD) were randomized to either medical therapy (N = 18) or unilateral GPi pallidotomy (N = 18). The primary outcome variable was the change in total Unified Parkinson's Disease Rating Scale (UPDRS) score at 6 months. Secondary outcome variables included subscores and individual parkinsonian symptoms as determined from the UPDRS. At the six month follow-up, patients receiving pallidotomy had a statistically significant reduction (32% decrease) in the… CONTINUE READING


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