Randomized trial of everolimus-facilitated calcineurin inhibitor minimization over 24 months in renal transplantation.

@article{Cibrik2013RandomizedTO,
  title={Randomized trial of everolimus-facilitated calcineurin inhibitor minimization over 24 months in renal transplantation.},
  author={Diane M. Cibrik and H{\'e}lio Tedesco Silva and A. Vani Vathsala and Eva Lackov{\'a} and Catherine Cornu-Artis and Rowan G. Walker and Zailong Wang and Gazi B. Zibari and Fuad S. Shihab and Yu Seun Kim},
  journal={Transplantation},
  year={2013},
  volume={95 7},
  pages={933-42}
}
BACKGROUND Strategies allowing calcineurin inhibitor minimization while maintaining efficacy may improve renal transplant outcomes. METHODS A2309 was a 24-month, phase IIIb, open-label trial of 833 de novo renal transplant recipients randomized to everolimus, targeting trough concentrations of 3-8 or 6-12 ng/mL plus reduced-exposure cyclosporine A (CsA… CONTINUE READING