Randomized trial of blood eosinophil count monitoring as a guide to corticosteroid dosage adjustment after heart transplantation.

@article{Trull2000RandomizedTO,
  title={Randomized trial of blood eosinophil count monitoring as a guide to corticosteroid dosage adjustment after heart transplantation.},
  author={Andrew K. Trull and Louise Steel and Linda D. Sharples and Fatemah Akhlaghi and Jayan K Parameshwar and Nathaniel R. B. Cary and John Wallwork and Stephen R. Large},
  journal={Transplantation},
  year={2000},
  volume={70 5},
  pages={802-9}
}
BACKGROUND Increases in blood eosinophil counts (EOS) beyond 0.06 x 10(9)/liter precede treated heart allograft rejection. An oral prednisolone dose of 0.35 mg/kg/day usually suppresses EOS below this threshold. METHODS We designed a randomized trial to compare our empirical protocol for steroid dose adjustment with a novel protocol guided by EOS… CONTINUE READING