Randomized trial of CD8+ T-cell depletion in the prevention of graft-versus-host disease associated with donor lymphocyte infusion.

@article{Soiffer2002RandomizedTO,
  title={Randomized trial of CD8+ T-cell depletion in the prevention of graft-versus-host disease associated with donor lymphocyte infusion.},
  author={Robert J. Soiffer and Edwin P Alyea and Ephraim Hochberg and Catherine Wu and Christine M. Canning and Bijal Parikh and David Zahrieh and Iain Webb and Joseph A Antin and Jerome Ritz},
  journal={Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation},
  year={2002},
  volume={8 11},
  pages={625-32}
}
The application of DLI is limited by the potential development of GVHD. Results of single-arm trials suggest that CD8+ depletion of DLI may reduce the incidence of GVHD while still inducing pathologic and cytogenetic remissions. To test the impact of CD8 depletion on GVHD, we initiated a randomized trial comparing outcome among patients receiving unselected donor lymphocytes or CD8+-depleted cells. DLI was administered to patients with disease in remission to prevent relapse 6 months after T… CONTINUE READING