Randomized study assessing the effect of digoxin withdrawal in patients with mild to moderate chronic congestive heart failure: results of the PROVED trial. PROVED Investigative Group.

@article{Uretsky1993RandomizedSA,
  title={Randomized study assessing the effect of digoxin withdrawal in patients with mild to moderate chronic congestive heart failure: results of the PROVED trial. PROVED Investigative Group.},
  author={Barry F Uretsky and James B. De Young and Fereidoon Shahidi and Laurence Yellen and Michael C. Harrison and M King Jolly},
  journal={Journal of the American College of Cardiology},
  year={1993},
  volume={22 4},
  pages={955-62}
}
OBJECTIVES The purpose of this study was to determine whether digoxin is effective in patients with chronic, stable mild to moderate heart failure. BACKGROUND Digoxin has been a traditional therapy in heart failure, but methodologic limitations in earlier studies have prevented definitive conclusions regarding its efficacy. METHODS Withdrawal of digoxin (placebo group, n = 46) or its continuation (digoxin group, n = 42) was performed in a prospective, randomized, double-blind, placebo… CONTINUE READING

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