Randomized single-blind trial in general practice comparing the efficacy and palatability of two cough linctus preparations, 'Pholcolix' and 'Actifed' Compound, in children with acute cough.

  title={Randomized single-blind trial in general practice comparing the efficacy and palatability of two cough linctus preparations, 'Pholcolix' and 'Actifed' Compound, in children with acute cough.},
  author={Gabriel V. Jaff{\'e} and J. J. Grimshaw},
  journal={Current medical research and opinion},
  volume={8 8},
Two hundred and seventeen patients between 6 and 12 years of age suffering from acute cough took part in a randomized, single-blind study comparing 'Pholcolix' and 'Actifed' Compound. No significant difference in efficacy was demonstrated but analysis of palatability components (taste, smell, aftertaste and feeling in the mouth) showed numerical superiority for 'Pholcolix' for all parameters, with a high degree of significance for overall taste. 'Pholcolix' caused significantly fewer side… 
Comparative Efficacy and Tolerability of Pholcodine and Dextromethorphan in the Management of Patients with Acute, Non-Productive Cough
Findings indicate that the efficacy of a 3-day course of pholcodine is similar to that of dextromethorphan in the treatment of adult patients with acute, non-productive cough.
Efficacy of cough suppressants in children.
Fixed‐dose combinations for cough and common cold in India: an assessment of availability and rationality
Rationality assessment of the FDC preparations revealed that most of the preparations were irrational and had no documented benefit in the treatment of common cold, which requires serious review of the legal provisions in India for drug manufacturing and marketing.
Antihistamines for the common cold (Withdrawn Paper. 2009, art. no. CD001267)
Antihistamines in monotherapy - in children as well as in adults - do not alleviate to a clinical extent nasal congestion, rhinorrhoea and sneezing, or subjective improvement of the common cold.
Use of codeine- and dextromethorphan-containing cough remedies in children. American Academy of Pediatrics. Committee on Drugs.
Education of patients and parents about the lack of proven antitussive effects of cough and cold preparations and the potential risks of these products is needed.
Over-the-counter cold medications. A critical review of clinical trials between 1950 and 1991.
No good evidence has demonstrated the effectiveness of over-the-counter cold medications in preschool children, and further studies are required to clarify the role of these medications in children.
Anti-histamines for prolonged non-specific cough in children.
The finding of uncertain efficacy of anti-histamines for chronic cough are similar to that for acute cough in children, in contrast to recommendations in adults with chronic cough.
Antihistamines for the common cold.
Antihistamines have a limited short-term beneficial effect on severity of overall symptoms but not in the mid to long term, and there is no clinically significant effect on nasal obstruction, rhinorrhoea or sneezing.
American Academy of Pediatrics
Current problems encountered with “inactive” ingredients include benzalkonium chloride-induced bronchospasm from antiasthmatic drugs, aspartameinduced headache and seizures, saccharin-induced cross-sensitivity reactions in children with sulfonamide allergy, benzyl alcohol toxicity in neonates receiving high-dose continuous infusion with preserved medications, and dye-related cross-reactions inChildren with aspirin intolerance.


Effects of pseudoephedrine and triprolidine, alone and in combination, on symptoms of the common cold.
Sneezing, nasal obstruction, and overall response to treatment were significantly improved with psuedoephedrine or pseudoephedine and triprolidine compared with placebo.
CNS effects of the antihistamines diphenhydramine and terfenadine (RMI 9918).
  • M. Fink, P. Irwin
  • Psychology
    Pharmakopsychiatrie, Neuro-Psychopharmakologie
  • 1979
The quantitative EEG profile of a putative antihistaminic drug, terfenadine, was determined in a crossover comparison with diphenhydramine in normal male volunteers and confirmed the lack of CNS effect observed in preclinical and clinical trials.