Randomized prospective evaluation of cimetidine and antacid control of gastric pH in the critically ill.

@article{Stothert1980RandomizedPE,
  title={Randomized prospective evaluation of cimetidine and antacid control of gastric pH in the critically ill.},
  author={Joseph C Stothert and David Simonowitz and E. Patchen Dellinger and Melissa Farley and W. A. Drew Edwards and Andrew D. Blair and Roy Cutler and Caroline Carrico},
  journal={Annals of surgery},
  year={1980},
  volume={192 2},
  pages={169-74}
}
One hundred forty-four critically ill patients admitted to an intensive care setting were randomly assigned to cimetidine or antacid treatament groups. Gastric pH was monitored hourly. One hundred twenty-three (85%) patients demonstrated a fall in pH to less than 4 and were considered to require prophylaxis. Prophylaxis was considered adequate if the measured pH could then be maintained at greater than or equal to 4. Fifty-eight patients received antacids alone, the average requirement being 41… CONTINUE READING

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