Randomized prospective clinical study of small, large and twice-a-day fraction radiotherapy for painful bone metastases.

@article{Okawa1988RandomizedPC,
  title={Randomized prospective clinical study of small, large and twice-a-day fraction radiotherapy for painful bone metastases.},
  author={Toshiaki Okawa and Midori Kita and Masahiro Goto and Hiroshi Nishijima and Natsuko Miyaji},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={1988},
  volume={13 2},
  pages={99-104}
}
A prospective randomized clinical trial comparing small, large and twice-a-day fraction for the relief of painful bone metastases was performed from 1981 to 1986 at Tokyo Women's Medical College Hospital. Eighty patients with painful bone metastases (92 sites) were divided into three radiation methods which were conventional fraction scheme of 5 times/week at 2 Gy/day for a total of 30 Gy/15 fractions (Group I, TDF: 49), 2 times/week at 4.5 Gy/day for a total of 22.5 Gy/5 fractions (Group II… CONTINUE READING