Randomized placebo-controlled trial of baclofen for cocaine dependence: preliminary effects for individuals with chronic patterns of cocaine use.

@article{Shoptaw2003RandomizedPT,
  title={Randomized placebo-controlled trial of baclofen for cocaine dependence: preliminary effects for individuals with chronic patterns of cocaine use.},
  author={Steven Shoptaw and Xiaowei Yang and Erin J Rotheram-Fuller and Ya-Ching M Hsieh and Prudencia C Kintaudi and V C Charuvastra and W Emily Ling},
  journal={The Journal of clinical psychiatry},
  year={2003},
  volume={64 12},
  pages={1440-8}
}
BACKGROUND This screening trial evaluated whether the GABAB agonist baclofen demonstrated sufficient clinical efficacy to recommend an adequately powered trial of the medication as a pharmacotherapy for cocaine dependence. METHOD Participants with cocaine dependence verified by the Structured Clinical Interview for DSM-IV were randomly assigned to baclofen (N = 35; 20 mg t.i.d.) or placebo conditions (N = 35; identical in appearance and dosage rate) using a 2-group, experimental, 16-week… CONTINUE READING
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