Randomized placebo-controlled trial of androgen effects on muscle and bone in men requiring long-term systemic glucocorticoid treatment.

@article{Crawford2003RandomizedPT,
  title={Randomized placebo-controlled trial of androgen effects on muscle and bone in men requiring long-term systemic glucocorticoid treatment.},
  author={Bronwyn A. L. Crawford and Peter Y Liu and Mary T Kean and Jane F. Bleasel and David J Handelsman},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2003},
  volume={88 7},
  pages={
          3167-76
        }
}
Long-term glucocorticoid therapy in men is associated with loss of bone and muscle mass as well as a decrease in serum testosterone. We tested the effect of two androgens, testosterone and its minimally aromatizable analog nandrolone, on muscle mass (dual x-ray absorptiometry), muscle strength (knee flexion and extension by isokinetic dynamometry), bone mineral density (BMD), and quality of life (Qualeffo-41 questionnaire) in 51 men on a mean daily prednisone dose of 12.6 +/- 2.2 mg. Men were… CONTINUE READING
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