Randomized placebo-controlled clinical trial of immunoglobulin Y as adjunct to standard supportive therapy for rotavirus-associated diarrhea among pediatric patients.

@article{Rahman2012RandomizedPC,
  title={Randomized placebo-controlled clinical trial of immunoglobulin Y as adjunct to standard supportive therapy for rotavirus-associated diarrhea among pediatric patients.},
  author={Shofiqur Rahman and Kyoko Higo-Moriguchi and Khaing Win Htun and Koki Taniguchi and Faustino C. Icatlo and Takao Tsuji and Yoshikatsu Kodama and Sa Van Nguyen and Kouji Umeda and Htun Naing Oo and Yi Yi Myint and Than Htut and Swe Swe Myint and Kyaw Thura and Hlaing Myat Thu and Ni Nengah Dwi Fatmawati and Keiji Oguma},
  journal={Vaccine},
  year={2012},
  volume={30 31},
  pages={4661-9}
}
This study aims to evaluate the effect of hyperimmune immunoglobulin Y (IgY) against human rotavirus (HRV) among pediatric patients receiving standard supportive treatment for rotavirus-associated diarrhea mostly with an enteric non-cholera co-pathogen in a hospital setting. Two natural HRV reassortant clinical strains ATCC VR 2273 and ATCC VR 2274 were used as mixed immunizing antigens in poultry hens to generate anti-HRV IgY (Rotamix IgY). The Rotamix IgY was used in laboratory and clinical… CONTINUE READING
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