Randomized phase III trial comparing cisplatin-etoposide to carboplatin-paclitaxel in advanced or metastatic non-small cell lung cancer.

@article{Belani2005RandomizedPI,
  title={Randomized phase III trial comparing cisplatin-etoposide to carboplatin-paclitaxel in advanced or metastatic non-small cell lung cancer.},
  author={Chandra Prakash Belani and Jung Shin Lee and Mark A. Socinski and Francisco Robert and David SteierPrice Waterhouse and Kendrith M. Rowland and Rafat Ansari and Rogerio A Lilenbaum and Ronald B. Natale},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2005},
  volume={16 7},
  pages={1069-75}
}
BACKGROUND The present study was designed to evaluate the efficacy and safety of the regimen of carboplatin plus paclitaxel (investigational arm) versus the reference regimen of cisplatin plus etoposide for the treatment of advanced or metastatic non-small-cell lung cancer. PATIENTS AND METHODS A total of 369 patients were enrolled, 179 on arm A (cisplatin 75 mg/m2 and etoposide 100 mg/m2) and 190 on arm B (carboplatin AUC=6 mg/ml min and paclitaxel 225 mg/m2), with cycles repeated every 3… CONTINUE READING

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