Randomized phase III intergroup trial of isotretinoin to prevent second primary tumors in stage I non-small-cell lung cancer.

@article{Lippman2001RandomizedPI,
  title={Randomized phase III intergroup trial of isotretinoin to prevent second primary tumors in stage I non-small-cell lung cancer.},
  author={Scott Michael Lippman and J Jack Lee and Daniel Karp and Everett E. Vokes and Steven E. Benner and Gary E. Goodman and Fadlo R. Khuri and Reinhard E. Marks and Rodger J. Winn and Willard A Fry and Stephen L. Graziano and David R. Gandara and Gordon S Okawara and C L Woodhouse and Brendell Williams and C Neyra P{\'e}rez and Hwal Woong Kim and Reuben Lotan and J. L. A. Roth and Waun Ki Hong},
  journal={Journal of the National Cancer Institute},
  year={2001},
  volume={93 8},
  pages={605-18}
}
BACKGROUND Promising data have suggested that retinoid chemoprevention may help to control second primary tumors (SPTs), recurrence, and mortality of stage I non-small-cell lung cancer (NSCLC) patients. METHODS We carried out a National Cancer Institute (NCI) Intergroup phase III trial (NCI #I91-0001) with 1166 patients with pathologic stage I NSCLC (6 weeks to 3 years from definitive resection and no prior radiotherapy or chemotherapy). Patients were randomly assigned to receive a placebo or… CONTINUE READING
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Retinoids, carotenoids and micronutrients

  • ST Mayne, SM Lippman
  • 2001

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