Randomized phase III clinical trial of five different arms of treatment for patients with cancer cachexia: interim results.

@article{Mantovani2008RandomizedPI,
  title={Randomized phase III clinical trial of five different arms of treatment for patients with cancer cachexia: interim results.},
  author={Giovanni Mantovani and Antonio Macci{\`o} and Clelia Madeddu and Giulia Gramignano and Roberto Serpe and Elena Massa and Mariele Dess{\`i} and Francesca Maria Tanca and Eleonora Sanna and Laura Deiana and Filomena Panzone and Paolo Contu and Carlo Floris},
  journal={Nutrition},
  year={2008},
  volume={24 4},
  pages={
          305-13
        }
}
OBJECTIVE In April 2005 a phase III randomized study was started to establish which was the most effective and safest treatment of cancer-related anorexia/cachexia syndrome and oxidative stress in improving identified primary endpoints: increase of lean body mass, decrease of resting energy expenditure (REE), increase of total daily physical activity, decrease of interleukin-6 and tumor necrosis factor-alpha, and improvement of fatigue assessed by the Multidimensional Fatigue Symptom Inventory… CONTINUE READING

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