Randomized phase 3 trial comparing preoperative and postoperative chemoradiotherapy with capecitabine for locally advanced rectal cancer.

@article{Park2011RandomizedP3,
  title={Randomized phase 3 trial comparing preoperative and postoperative chemoradiotherapy with capecitabine for locally advanced rectal cancer.},
  author={Jin-Hong Park and Sang Min Yoon and Chang Sik Yu and Jong Hoon Kim and Tae Won Kim and Jin Cheon Kim},
  journal={Cancer},
  year={2011},
  volume={117 16},
  pages={3703-12}
}
BACKGROUND Although many trials have shown the efficacy of preoperative chemoradiotherapy (CRT) or postoperative CRT compared with surgery alone, the optimal sequence of radiotherapy and surgery is unclear. The authors reported the final results of this single institution prospective randomized phase 3 trial comparing preoperative CRT with postoperative CRT using capecitabine in survival, local control, sphincter preservation, and toxicity for the treatment of locally advanced rectal cancer… CONTINUE READING