Randomized multicenter phase 2 study of pomalidomide, cyclophosphamide, and dexamethasone in relapsed refractory myeloma.

@article{Baz2016RandomizedMP,
  title={Randomized multicenter phase 2 study of pomalidomide, cyclophosphamide, and dexamethasone in relapsed refractory myeloma.},
  author={Rachid Baz and Thomas R. Martin and Hui-Yi Lin and Xiuhua Zhao and Kenneth Shain and Hearn Jay Cho and Jeffrey Wolf and Anuj Mahindra and Ajai Chari and Daniel Sullivan and Lisa A. Nardelli and Kenneth Kwok-Pan Lau and M. Sabes Alsina and Sundar Jagannath},
  journal={Blood},
  year={2016},
  volume={127 21},
  pages={2561-8}
}
Pomalidomide and low-dose dexamethasone (PomDex) is standard treatment of lenalidomide refractory myeloma patients who have received >2 prior therapies. We aimed to assess the safety and efficacy of the addition of oral weekly cyclophosphamide to standard PomDex. We first performed a dose escalation phase 1 study to determine the recommended phase 2 dose of cyclophosphamide in combination with PomDex (arm A). A randomized, multicenter phase 2 study followed, enrolling patients with lenalidomide… CONTINUE READING
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