Randomized double-blinded comparison of norepinephrine and phenylephrine for maintenance of blood pressure during spinal anesthesia for cesarean delivery.

@article{Kee2015RandomizedDC,
  title={Randomized double-blinded comparison of norepinephrine and phenylephrine for maintenance of blood pressure during spinal anesthesia for cesarean delivery.},
  author={Warwick D Ngan Kee and Shara Wee-Yee Lee and Floria F. Ng and Perpetua E. Tan and Kim Sun Khaw},
  journal={Anesthesiology},
  year={2015},
  volume={122 4},
  pages={
          736-45
        }
}
BACKGROUND During spinal anesthesia for cesarean delivery, phenylephrine can cause reflexive decreases in maternal heart rate and cardiac output. Norepinephrine has weak β-adrenergic receptor agonist activity in addition to potent α-adrenergic receptor activity and therefore may be suitable for maintaining blood pressure with less negative effects on heart rate and cardiac output compared with phenylephrine. METHODS In a randomized, double-blinded study, 104 healthy patients having cesarean… CONTINUE READING

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