Randomized double-blind study of botulinum toxin type B for sialorrhea in ALS patients.

@article{Jackson2009RandomizedDS,
  title={Randomized double-blind study of botulinum toxin type B for sialorrhea in ALS patients.},
  author={Carlayne E. Jackson and Gary S. Gronseth and Jeffrey Rosenfeld and Richard J Barohn and Richard Dubinsky and Charles B Simpson and April L. McVey and Pamela Kittrell and Ruth C. King and Laura L Herbelin},
  journal={Muscle & nerve},
  year={2009},
  volume={39 2},
  pages={137-43}
}
Twenty ALS patients with sialorrhea refractory to medical therapy were enrolled in this double-blind, randomized study to receive either 2,500 U of botulinum toxin type B (BTxb) or placebo into the bilateral parotid and submandibular glands using electromyographic guidance. Patients who received BTxb reported a global impression of improvement of 82% at 2 weeks compared to 38% of those who received placebo (P < 0.05). This significant effect was sustained at 4 weeks. At 12 weeks, 50% of… CONTINUE READING

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