Randomized, double-blind, placebo-controlled study about the effects of cannabidiol (CBD) on the pharmacokinetics of Delta9-tetrahydrocannabinol (THC) after oral application of THC verses standardized cannabis extract.

Abstract

Cannabidiol (CBD) is known to modify the effects of Delta-tetrahydrocannabinol (THC) by decreasing anxiety and antagonizing other THC-effects. As a reason, pharmacodynamic as well as pharmacokinetic mechanisms were suggested. In context of the use of cannabis-based medicine extracts for therapeutic purposes, a study was performed in a double-blind and… (More)

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Cite this paper

@article{Nadulski2005RandomizedDP, title={Randomized, double-blind, placebo-controlled study about the effects of cannabidiol (CBD) on the pharmacokinetics of Delta9-tetrahydrocannabinol (THC) after oral application of THC verses standardized cannabis extract.}, author={Thomas Nadulski and Fritz Pragst and Gordon Weinberg and Patrik Roser and Martin Schnelle and Eva-Maria Fronk and Andreas Michael Stadelmann}, journal={Therapeutic drug monitoring}, year={2005}, volume={27 6}, pages={799-810} }