Randomized, double-blind, placebo-controlled, dose-response, and preclinical safety study of transforaminal epidural etanercept for the treatment of sciatica.

Abstract

BACKGROUND Recent evidence implicates the inflammatory cytokine tumor necrosis factor as a major cause of radiculopathy. Yet, whereas open-label studies with systemically delivered tumor necrosis factor inhibitors have yielded positive results, a placebo-controlled study failed to demonstrate efficacy. One variable that may have contributed to poor outcomes… (More)
DOI: 10.1097/ALN.0b013e3181a05aa0

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@article{Cohen2009RandomizedDP, title={Randomized, double-blind, placebo-controlled, dose-response, and preclinical safety study of transforaminal epidural etanercept for the treatment of sciatica.}, author={Steven Paul Cohen and Nikolai Bogduk and Anthony Dragovich and Chester C. Buckenmaier and Scott Griffith and Connie Kurihara and Jolynne Raymond and Philip J. Richter and Necia Williams and Tony L. Yaksh}, journal={Anesthesiology}, year={2009}, volume={110 5}, pages={1116-26} }