Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer

@article{Heo2013RandomizedDC,
  title={Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer},
  author={Jeong Sook Heo and Tony R. Reid and Leyo Ruo and Caroline J. Breitbach and Steven B. Rose and Mark P Bloomston and Mong Cho and Ho-yeong Lim and Hyun Cheol Chung and Chang Won Kim and James Brian Burke and Riccardo A Lencioni and Theresa Hickman and Anne Moon and Yeon sook Lee and Mi Kyeong Kim and Manijeh Daneshmand and Kara Dubois and Lara Longpre and Minhtran V. Ngo and Cl{\'i}ona Rooney and John Cameron Bell and Byung-Geon Rhee and Richard H Patt and Tae-ho Hwang and David H. Kirn},
  journal={Nature Medicine},
  year={2013},
  volume={19},
  pages={329-336}
}
Oncolytic viruses and active immunotherapeutics have complementary mechanisms of action (MOA) that are both self amplifying in tumors, yet the impact of dose on subject outcome is unclear. JX-594 (Pexa-Vec) is an oncolytic and immunotherapeutic vaccinia virus. To determine the optimal JX-594 dose in subjects with advanced hepatocellular carcinoma (HCC), we conducted a randomized phase 2 dose-finding trial (n = 30). Radiologists infused low- or high-dose JX-594 into liver tumors (days 1, 15 and… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 274 CITATIONS, ESTIMATED 50% COVERAGE

Designing the Next-generation Oncolytic Vaccinia Virus

VIEW 30 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Fighting Cancer with Mathematics and Viruses

VIEW 5 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Oncolytic Virus-Based Immunotherapies for Hepatocellular Carcinoma

VIEW 11 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Avian influenza virus as an oncolytic therapy for pancreatic cancer

VIEW 23 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

New perspectives on the management of hepatocellular carcinoma with portal vein thrombosis

  • Clinical and molecular hepatology
  • 2015
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2013
2019

CITATION STATISTICS

  • 24 Highly Influenced Citations

  • Averaged 30 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 21 REFERENCES

Changes in tumor density in patients with advanced hepatocellular carcinoma treated with sunitinib.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2011

Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans

CJ Breitbach
  • 2011

Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial

AL Cheng
  • Lancet Oncol
  • 2009

Similar Papers

Loading similar papers…