Randomized controlled trials of surgical interventions.

@article{Farrokhyar2010RandomizedCT,
  title={Randomized controlled trials of surgical interventions.},
  author={Forough Farrokhyar and Paul J Karanicolas and Achilleas Thoma and Marko {\vS}imunovi{\'c} and Mohit Bhandari and P J Devereaux and Mehran Anvari and Anthony Adili and Gordon Guyatt},
  journal={Annals of surgery},
  year={2010},
  volume={251 3},
  pages={
          409-16
        }
}
BACKGROUND AND OBJECTIVES Surgical trials pose many methodological challenges often not present in trials of medical interventions. If not properly accounted for, these challenges may introduce significant biases and threaten the validity of the results. METHODS We systematically reviewed the significance of randomized controlled trials in the evaluation of surgical interventions, discussed the methodological challenges encountered in designing and conducting randomized controlled trials of… CONTINUE READING

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